Caution should be exercised in animals administered potassium-depleting steroids. Excessive loss of potassium in patients receiving digitalis or its glycosides may precipitate digitalis toxicity. Therefore, the animal should be observed for early signs of fluid depletion with electrolyte imbalance, and corrective measures administered. Warningsįurosemide tablets are a highly effective diuretic and, if given in excessive amounts, as with any diuretic, may lead to excessive diuresis which could result in electrolyte imbalance, dehydration and reduction of plasma volume, enhancing the risk of circulatory collapse, thrombosis and embolism. Monitor serum potassium levels and watch for signs of hypocalcemia.Ĭorticosteroids cause an additive potassium-depletion effect. Monitor serum electrolytes, BUN and CO2 frequently. Furosemide is contraindicated in anuria, furosemide hypersensitivity, hepatic coma, or during electrolytic imbalances. ContraindicationsĪnimal reproductive studies have shown that furosemide may cause fetal abnormality and the drug is contraindicated in pregnant animals. In refractory or severe edematous cases, the dosage may be doubled or increased by increments of 1 mg per pound body weight as recommended in preceding paragraphs, “Dosage and administration”. One 12.5 mg scored tablet per 5 to 10 pounds body weight.Īdminister once or twice daily, permitting a 6- to 8-hour interval between treatments. Dosage: Oralĭog: One-half to one 50 mg scored tablet per 25 pounds body weight. Abnormalities should be corrected or the drug temporarily withdrawn. Clinical examination and serum BUN, CO 2 and electrolyte determinations should be performed during the early period of therapy and periodically thereafter, especially in refractory cases. Re-examination and consultations with the client will enhance the establishment of a satisfactorily programmed dosage schedule. For long-term treatment, the dose can generally be lowered after the edema has once been reduced. Mobilization of the edema may be most efficiently and safely accomplished by utilizing an intermittent daily dose schedule, i.e., every other day or 2 to 4 consecutive days weekly.ĭiuretic therapy should be discontinued after reduction of the edema, or maintained after determining a carefully programmed dosage schedule to prevent recurrence of edema. The daily schedule of administration can be timed to control the period of micturition for the convenience of the client or veterinarian. The established effective dose should be administered once or twice daily. In severe edematous or refractory cases, the dose may be doubled or increased by increments of 1.0 mg per pound of body weight. The dosage should be adjusted to the individual’s response. A prompt diuresis usually ensues from the initial treatment.Īdminister orally once or twice daily at 6 to 8 hour intervals. The usual oral dosage of furosemide tablets is 1 to 2 mg/lb body weight (approximately 2.5 to 5 mg/kg). The rationale for efficacious use of diuretic therapy is determined by the clinical pathology producing the edema. In cases of edema involving cardiac insufficiency, the continued use of heart stimulants such as digitalis or its glycosides is indicated. 1,2,4,5,6 Furosemide Tablets Indicationsĭogs - Furosemide tablets are indicated for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute non-inflammatory tissue edema. The drug possesses diuretic activity either in the presence of acidosis or alkalosis. Furosemide tablets have no inhibitory effect on carbonic anhydrase or aldosterone activity in the distal tubule. The low lipid solubility and a rapid renal excretion minimize the possibility of its accumulation in tissues and organs or crystalluria. The prompt onset of action is a result of the drug’s rapid absorption and a poor lipid solubility. 1Ĥ) A high degree of efficacy, low inherent toxicity and a high therapeutic index.Īctions: The therapeutic efficacy of Furosemide tablets is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule but also in the ascending limb of the loop of Henle.

3ģ) A dose-response relationship and a ratio of minimum to maximum effective dose range greater than tenfold. 1,2Ģ) Is a loop diuretic which inhibits reabsorption of sodium and chloride at the ascending loop of Henle in the kidneys, enhancing water excretion. It is easily absorbed from the intestinal tract and begins to act in 30 to 60 minutes after oral administration.

Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid.įurosemide is pharmacodynamically characterized by the following:ġ) It is administered orally.

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